Microwave Assisted Synthesis, Molecular Docking Studies of New N-{[5-(Phenyl)-1,3,4-Thiadiazole-2-Yl]Carbamothioyl} Derivatives As Potent Antimicrobial Agents

Series of 1,3,4-thiadiazole derivatives were synthesized under microwave irradiation and evaluated for antimicrobial activity. Thiadiazole belong to the classes of nitrogen-sulfur heterocycles with extensive application as structural units of biologically active molecules and as useful intermediates in medicinal chemistry. The potency of the thiadiazole nucleus is demonstrated by the drugs currently used. 1,3,4-thiadiazoles and some of their derivatives are extensively studied because of their broad spectrum of pharmacological activities. Many of the reported 1,3,4-thiadiazole derivatives can be considered as lead compounds for drug synthesis, and several of them have demonstrated higher antimicrobial activity in comparison to standard drugs. Furthermore, taking into account the reactivity of the amine group in the derivatization process, All the compounds have been evaluated for their antimicrobial activities against several in-vitro strains of microbes and show significant activity. All the synthesized compounds were tested for in-vitro antibacterial (against Escherichia coli, Bacillus substilis, and Staphylococcus aureus) and antifungal activity (against Aspergillus Niger). Compound code 3d showed better inhibition as compared to the standard Ciprofloxacin and 3d showed good inhibition as compared to the standard Ketoconazole.