Role of FOXO3 Gene Polymorphism at Development of Primary Knee Osteoarthritis Disease in Iraqi Patients

Primary Knee osteoarthritis (PKOA) is disease occur in knee joint characterize by cartilage degradation that mediate via pro-inflammatory marker such as matrix metalloproteinase-13 (MMP-13) . Forkhead box (FoxO ) proteins are a subgroup of the Forkhead family of transcription factors ,which were originally identified in Drosophila as a gene whose mutation resulted in ectopic head structures that look like a fork . Cartilage cells obtained from human joints affected by OA , the cells had a reduced activity of genes producing FoxO proteins and reduced activity of autophagy genes.