Effects of Serotonin and Cortisol Hormones on Development of Diabetes Mellitus Type 2 Disease Authors

Diabetes Mellitus (DM) type 2 is chronic metabolic disease that characterized by elevation of serum glucose level (hyperglycemia) due to insulin hormone reduce or insulin cells resistance, that generate many complications such as retinopathy. Serotonin is hormonal neurotransmitter commonly found in brain cell but it also present in beta cells of pancreas. It is key hormone that stabilizes mood, feelings of well-being, and happiness. cortisol hormone is steroid hormone product and release by some of adrenal gland layers with a diurnal cycle manner and consider as primary stress hormone , it play role in many functions in body such as bio-molecular metabolisms . The objective of the study is the effects of serotonin and cortisol hormones on development of DM type 2 disease. Also the present study Included this study compared between un-control DM type2 patients (group 1) and controls persons (group 2) , all individuals in this study were age 50-60 years of both genders .All individuals were measured serum serotonin and cortisol hormones level with focus on present of depression or not .Results of study shows reduce of serum serotonin concentration level with increase of cortisol concentration level in uncontrol DM type 2 group compare with control group. Also the un-control DM type 2 group have depression situation when compare with control group . This study confirms that decreased serum serotonin concentration level and increase of cortisol concentration level can act as support to development of DM type 2 disease