Background: India reported its first cases of COVID 19 in a group of returned Indian medical students from Wuhan to Kerala in January 30, 2020. Tamilnadu reported its first case on March 7, 2020 in Kanchipuram. Disease prognosis worsen when associated with various comorbidities. Understanding the impact of demography and various comorbidities on the disease outcome is a crucial public health issue. Aim: We aim to identify the patients hospitalized for COVID-19 that are associated with various comorbidities along with increased risk of death. Method: The study was a statistical analysis of observational data in Tamilnadu, South India. Patients admitted with COVID- 19 from May 1, 2021 to May 15, 2021 were enrolled. Electronic data records were analyzed for demography and comorbidities. Results: 2678 patients (Male = 1689 & Female = 989) were enrolled. Mean (average) age was 63 years (20 – 100). Death risk was significantly influenced by gender. Mean duration of hospitalization was 4.9 days (0 – 39) with older patients and men staying longer (P<0.05). Comorbidities of diabetes, hypertension, coronary artery disease, obesity, cancer, thyroid disorders, autoimmune disorders, other heart diseases, other kidney diseases and other comorbidities were associated with higher risk of mortality univariate, but Hypertension and obesity reached statistical significance after adjustment of age and gender. Conclusion: COVID-19 outcome was worse in older people and those with comorbidities. Males and older patients required longer hospitalization. Females were at higher risk of mortality due to their low survival period in hospitals.
