A Study On Release Rate From Tramadol HCl Loaded Microspheres Prepared By Using Different Polymers.


Ritesh Bathe, Audumbar Mali, Sagar Kale
Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India.

Jitendra Pande
Department of Pharmaceutics, NRI Institute of Pharmacy, Raisen Road, Gopal Nagar, Bhopal, Madhya Pradesh, India.


Tramadol which is an opioid analgesic used to treat moderate to moderately severe pain act primarily by binding to the μ-opioid receptor and secondly by inhibiting the reactivity of norepinephrine and serotonin. The emulsion solvent evaporation method was used to encapsulate the polymers EC, HPMC K4M, and CAP, and characterization of formulations was performed. The microspheres obtained were white and spherical. The in vitro studies of the microspheres was performed using phosphate buffer of pH 6.8 at a temperature of 37 degrees Celsius and 100 rpm in 900ml USP basket type dissolution rate test apparatus for 8 hours and various parameters of the formulation were evaluated. Formulation F6 exhibited a higher yield and formulation of F3 entrapped maximum drug. The effect of the nature of polymer and polymer content was clearly visible on the drug release. The controlled release of the drug from the tramadol hydrochloride microsphere provides enhanced plasma drug content and higher bioavailability.