Anti-arthritic and Thrombolytic activity of leaves of Cordia dichotoma

The present study was designed to investigate the anti-arthritic and thrombolytic activity of Cordia dichotoma and phytochemical analysis of an ethanolic extract of leaves of Cordia dichotoma. Inhibition of protein denaturation was evaluated to assess the anti-arthritic effect of the selected plant materials. Denaturation was induced by incubating the extract with bovine albumin under various controlled conditions. The protein denaturation was calculated by measuring the absorbance of different concentrations. The thrombolytic activity has been assessed by human volunteer blood. Then all the activities are done in vitro on leaves of Cordia dichotoma. The ethanolic extract of leaves of Cordia dichotoma shows significant anti-arthritic and thrombolytic activity. The inhibition of protein denaturation was found to be 79.12 % at a concentration of 1000µg/ml in anti-arthritic activity and that of % clot lysis was found to be 31.23 % in thrombolytic activity. From this above study, we concluded that the leaves of Cordia dichotoma show significant anti-arthritic and thrombolytic activity.