Anti-Diabetic and Anti-Hyperlipidemic Effects of Polyherbal Ethanolic Extracts(Allium sativum, Vinca rosea & Mangifera indica)in Streptozotocin Induced Hyperglycemic Rats

The investigation of herbalblendsmay be a different way of producing medication in order to have improved outcomes or advantages in the treatment of diseases. Allium sativum, Vinca rosea and Mangifera indica are three medicinal plants that are already well-known for the treatment of diabetes mellitus, but separately. The combined potent hypoglycemic effect of these plants is expected to achievethe finest antidiabetic effect. This research aims to assess diabetic condition of rats induced by a single dose of 60mg/kg BW streptozotocin intra-peritoneally. The diabetic rats were administered orally with a combination of plant extracts (150mg/kg BW in equal ratio of each extract) for a period of 28 days. Hematological parameters (RBC count, total Hb count), Lipid parameters (TG, serum cholesterol, LDL, VLDL and HDL) and blood glucose levels were evaluated. The study revealed that the lipid parameters and blood glucose levels were profoundly decreased in diabetic rats suggesting the polyherbal extracts as an effective antidiabetic agent.