Anticonvulant Potentail of the Oxazetidine Derivatives

Anticonvulsant potential of the 2-[3-chloro-2-(4-chlorophenyl)-4-oxoazetidin-1-yl]-3-(1H-indol-3-yl)propanoic acid (NL2(2)), 2-[3-chloro-2-(4-methoxyphenyl)-4-oxoazetidin-1-yl]-3-(1H-indol-3-yl)propanoic acid (NL2(3)), 2-[3-chloro-2-(3-nitrophenyl)-4-oxoazetidin-1-yl]-3-(1H-indol-3-yl)propanoic acid (NL2(4)) has been reported. The anticonvulsant activity have been carried out via maximal electroshock (MES) induced convulsion and Pentylenetetrazole (PTZ) induced convulsion model. Biochemical analysis for both models have been performed via analysis of Malondialdehyde (MDA), reduced Glutathione (GSH) reagent estimation and measurement of Catalase activity and SOD activity. Derivative 2-[3-chloro-2-(4-methoxyphenyl)-4-oxoazetidin-1-yl]-3-(1H-indol-3-yl)propanoic acid (NL2(3)) exhibited potent and having comparable bioactivity to the standard in both animal models.