Assessment Antiarthritic Potential of Naproxen through In-silico Molecular docking


Priyanka Ahirwar, Research scholar, Dr. K. Saravanan
Department of Pharmacy, Bhagwant Global University, Kotdwar, Uttarakhand, India.


Arthritis destroys the cartilage that normally protects joints. Arthritis causes not only hyperplasia of synovial cells, but also an inflammatory response. Naproxen (Np) is one of the oldest and best-selling non-selective NSAIDs, inhibiting both her COX isoforms with comparable IC50 values. Naproxen is a more potent COX-2 inhibitor than COX-I. Naproxen sodium (Ns), the sodium salt form of naproxen (Np), is more effective than other NSAIDs in treating knee osteoarthritis. It is also used to treat rheumatic diseases such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and non-rheumatoid arthritis. In a recent study, the anti-arthritic potential of naproxen was elucidated by in-silico molecular docking via binding interactions between naproxen and the NF-κβ enzyme.