Combined effect of Levothyroxine, Antihyperlipidemic and oral hypoglycemic agents on lipid profile and cognition level in hypothyroidism patients

Aim: To evaluate the effect of combination therapy on lipid profile and cognition level in hypothyroidism patients. Methods: A prospective observational study was conducted in a private hospital at Tiruchengode. Patients who were under the management of thyroid disorder and hyperlipidemia more than 10 years was screened and selected for the study. There were 155 patients were included in the study and the patients who were on Levothyroxine 50mcg as control (Group 1), Group 2 Patients prescribed with levothyroxine 50mcg and Atorvastatin 20mg were checked with lipid profile parameter like Total cholesterol (TC), Triglycerides (TG), High density Lipoprotein (HDL-C), Low density Lipoprotein (LDL-C) and compared with control group values. Group 3 patients prescribed with levothyroxine 50mcg and Atorvastatin 20mg, Glimepride 2mg, Metformin 500mg were checked with lipid profile, compared with control group. The patients were interviewed using a Mini mental state examination questionnaire and their cognitive skills were assessed and compared with control group. Independent samples T test was used to compare the complication of the management. Conclusion: Hyperlipidemia management with levothyroxine 50mcg and Atorvastatin 20mg, Glimepride 2mg, Metformin 500mg (Group 3) has an association on the managing lipid profile efficiently than the control (Group 1) Significant (p<0.01). Cognition impairment was high in the combination therapy. (p <0.01)