Correlation of Lactate Dehydrogenase (LDH) activity, D-Dimer and Severity in a sample of COVID-19 patients in Iraq

Subject: The coronavirus pandemic, which began in 2019, is a global outbreak of coronavirus disease. The World Health Organization (WHO) also classified Severe Acute Respiratory Syndrome (SARS) as a new coronavirus (SARS-CoV-2). Wuhan, China, was the first place in December 2019 when the pandemic was found. LDH levels were related to a six-fold increase in the risk of developing severe COVID-19 disease. The objective of the study: Estimation of enzyme activity of Lactate Dehydrogenase enzyme (LDH) and d-dimer in patients with COVID-19 to estimate the behavior of enzyme during the period of the disease. Correlation of enzyme activity Lactate Dehydrogenase (LDH)with d-dimer. More crucially, elevated LDH was related to a 16-fold increase in the risk of death. Abnormal coagulation function, including elevated D-dimer, has been demonstrated to be more common in deceased patients with COVID-19, and increasing odds of in-hospital death were associated with D-dimer greater than 1 μg/ml. The current study aimed to investigate serum levels of LDH and d- dimer in the severity of COVID-19 patients and to clarify the correlation of these parameters with disease severity Material and method: This study included (48) patients with COVID-19 in severity (confirmed by polymerase chain reaction). COVID-19 patients showed a significant elevation in the levels of all parameters, we concluded a proportional correlation between the aforementioned parameters and COVID-19 suggesting the uses of these tests to the diagnosis of severe cases. Results: This study showed a high correlation between the activity of lactate dehydrogenase (LDH) and disease progression and severity in patients with COVID-19. Also, the study showed a high correlation between D-dimer and disease progression and severity in patients with COVI19. Conclusion: There is a correlation between lactate dehydrogenase (LDH)level and D- dimer level later on during disease Progression. But not and the time of hospitalization.