“DESIGN AND DEVELOPMENT OF SOME NOVEL HETEROCYCLIC COMPOUNDS TARGETED FOR NAV1.7”

Pain is generally known as a disruptive sentiment which is results of forceful and damaging stimuli. Neuropathic pains (NP) are regularly associated with the chronic form which is result of the injury in the somatosensory nerves. 8-10% of the general population is found to be affected by neuropathic pain and it is normally associated with the sever clinical condition as more than 60 % of cases are associated with diabetic, cancer and other several injuries. To overcome of these need to synthesis novel heterocyclic compounds.1,3, 4-Oxadiazole ring has a crucial important in heterocyclic chemistry and have extensive utilization in screening for various biological activities. 1, 3, 4-Oxadiazole and Indole containing compounds have been gained considerable attention in pharmaceutical field due to their remarkable bioactivities. 6 different heterocyclic derivatives from Indole substituted Oxadiazole class were synthesized Molecules that are synthesized are characterized via by IR, Mass, C13 and H1 NMR spectral analysis. All the synthesized derivatives were found to be networking with Nav 1.7 which indicated further biological optimization of these compounds may lead to strong Nav 1.7inhibitors. Neuropathic pain activity of synthesized compound carried out by streptozocine (STZ) induced diabetic pain model.