Epidemiology of Multi-Drug Resistant Gram-Negative Uropathogens in South India


Thirunavukkarasu Periyasamy
Department of Biotechnology, Nehru Arts and Science College, Coimbatore 641005, TamilNadu, India.


Multi-drug-resistant bacteria surveillance (MDR) systems were used to identify the epidemiology of MDR bacteria in urinary tract infection (UTI) and non-UTI Patients for a period of 12 months collected from the regions of Tamil Nadu, South India. This study aimed to isolate colonies of MDR bacteria which were cultured on suitable selective media and identified by biochemical analysis as well as isolates of Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa from the UTI and non-UTI patients. We screened a total of 1542 samples. A total of 532 strains of bacterial isolates belonging to 4 species were isolated. Among the clinical samples, E. coli was highly predominant in urine samples. Various antimicrobial activities were performed and higher resistance was observed at 86.2%, 95.2% and 46.0% to Ampicillin-sulbactum, and lowest resistance was observed to meropenem and colistin (7.8%). The MDR of four UTI and non-UTI causing bacteria was recorded in this study, which indicated that the bacteria were resistant to each antibiotic study in public health, particularly E. coli, K. pneumoniae, A. baumannii and P. aeruginosa. These findings confirm that antimicrobial resistance rates vary for different pathogens.