Evaluation of S-Adenosylmethionine (SAM), Folic acid and cobalamin levels in a samples of Iraqi patients with Severe & Critical coronavirus disease 2019 (COVID‐19)


Duraid Jaafar Bakir, Hassan H. Taha Al-Saeed, Haider Abdul Hameed Alqaraghuli
College of Medicine, Al-Nahrain University, Iraq.


Coronavirus disease 2019 (COVID-19), a newly identified respiratory illness caused by the SARS-CoV-2 (severe acute respiratory syndrome coronavirus), has recently gone pandemic. To replicate from the host's S.adenosylmethionine (SAM) and trigger the virally produced T- cell and macrophage-mediated cytokine storm, the coronavirus RNA cap structure is methylated, which appears to be a primary cause of COVID-19 mortality. Folate is required for the metabolism of nucleic acid precursors, certain amino acids, and methylation processes. SARS – COV-2, on the other hand, may disrupt vitamin B12 metabolism, limiting microbial proliferation in the intestine. Vitamin B12 deficient symptoms, such as enhanced oxidative stress and lactate dehydrogenase, as well as renal and pulmonary vasculopathy, are similar to COVID-19 infection symptoms.