Evaluation of Urinary Oxidative stress Marker and presence of microalbuminuria in patients with Covid-19 disease as a measure of kidney involvement

subject: COVID19 virus, as of those being pandemic, infected millions of humans dead and because of the unknown impact of the pandemic on the population .in Wuhan is a new coronavirus discovered in China in December 2019. By WHO, it is predicted that, by March 11, 2020, the disease pandemic will have spread throughout the world. Must patient was found elevated D- Dimer, oxidative stress reactive oxygen species (ROS), and fasting blood sugar. Besides, increase blood urea and end with dialysis. the objective of the study: To better understand coronavirus disease 2019 (COVID-19) by finding possible predictors for kidney damage by a correlation between microalbuminuria and albumin creatinine ratio (ACR)with oxidative stress marker 8-epi-prostaglandin F2alpha in urine Material and method:- group I; consist 80 participants (male &female ) hospitalization with covid 19 severe and non sever (confirmed by polymerase chain reaction) COVID-19 patients showed a significant elevation in the levels of albuminuria and oxidative stress marker, we concluded a proportional correlation between the aforementioned parameters and COVID-19 suggesting the uses of these tests to the diagnosis early kidney damage. -group II: consist of 80 participants (male &female ) recovering from coronavirus as a control Results: This study showed a high correlation between Albuminurea and albumin creatinine ratio (ACR) with oxidative stress marker8-epi-prostaglandin F2alpha in non-severe and severe in patients with COVID-19. Also, the study showed a high correlation between D-dimer and disease progression and severity in patients with COVI19. Conclusion: There is a correlation between Albuminurea and albumin creatinine ratio (ACR) with oxidative stress marker8-iso -prostaglandin F2alpha in non-severe and severe in patients with COVID-19 during Progression Keywords: COVID-19, Severe Acute Respiratory Syndrome (SARS), ACR oxidative stress, 8-epi-prostaglandin F2alpha lipid peroxidation, and albuminuria.