Formulation Development And Evaluation Of Immediate Release Tablets Of Anti-Malarial Drug For Effective Management Of Malaria.

A quinoline called hydroxychloroquine sulfate, or HCQ, is used to treat and prevent rheumatoid arthritis, lumpus erythematosus, and simple malaria. HCQ is a weight-based treatment option for pediatric and adolescent patients for each indication; however, there isn't a pediatric medication that is specifically designed for this market. It is possible to combine a pediatric taste-masking system with an adult immediate-release formulation to make it possible to make a palatable suspension with water using standard excipients. An ion-pairing system that is somewhat buffered has been shown to dramatically lessen the bitterness of HCQ, according to preliminary study. Since HCQ is a medication classified as Class 1 in the Biopharmaceutics Classification System, adding taste-masking and suspending substance to an adult tablet formulation would not change the pharmacokinetics of the adult immediate-release formulation.