Sanket T. Netke, Dr. Santosh Tarke, Dr. Gitanjali Chavan, Mr. Vishal Sakhare, Mrs. Ashwini Gholkar
Department of Pharmaceutics, SBSPMs College of Pharmacy, Ambajogai, Beed, Maharashtra, India.
Formulation Development And Evaluation Of Immediate Release Tablets Of Anti-Malarial Drug For Effective Management Of Malaria.
Authors
Abstract
A quinoline called hydroxychloroquine sulfate, or HCQ, is used to treat and prevent rheumatoid arthritis,
lumpus erythematosus, and simple malaria. HCQ is a weight-based treatment option for pediatric and
adolescent patients for each indication; however, there isn't a pediatric medication that is specifically
designed for this market. It is possible to combine a pediatric taste-masking system with an adult
immediate-release formulation to make it possible to make a palatable suspension with water using
standard excipients. An ion-pairing system that is somewhat buffered has been shown to dramatically
lessen the bitterness of HCQ, according to preliminary study. Since HCQ is a medication classified as
Class 1 in the Biopharmaceutics Classification System, adding taste-masking and suspending substance
to an adult tablet formulation would not change the pharmacokinetics of the adult immediate-release
formulation.