V.T. Mankoskar, Corresponding Author, G. V.Lohiya, R.R.Sarda,
Dayanand College of Pharmacy, Latur, Maharashtra, India.
R. M. Somani
Macleods Pharmaceuticals Ltd, Mumbai, Maharashtra, India.
Dr. S.S.Dharashivkar
Dr. L. H. Hiranandani college of Pharmacy, Ulhasnagar, Maharashtra, India.
Dr. S. G. Gattani
School of Pharmacy, S.R.T.M. University, Nanded, Maharashtra, India.
Dr. S.S.Tiwari
Annasaheb Dange College of B.Pharmacy, Ashta, Sangli, Maharashtra, India.
In Situ Gelling Nasal Drug Delivery System
Authors
Abstract
In the nasal cavity, nasal mucosa had a high blood perfusion rate, due to this the absorption of the
drug is high as compared to other routes, as well as has increased good bioavailability of drugs at
the systemic circulation. To improve the nasal retention time of in-situ gel with nasal mucosa we
have to use bio-compatible mucoadhesive polymer. In-situ gel nasal drug transfermethod is the
type of mucoadhesive drug delivery system. When the drug is administered through nasal route
then the first-pass metabolism gets reduced, had less enzymatic reaction occurrence, and prevents
gastrointestinal tract ulceration. Drug release kinetic can be controlled by gelation strength of the
formulation and viscosity of the in-situ gel formulation, so in-situ gel nasal drug delivery is also
called a controlled and sustained drug delivery system. In-situ gels are prepared by various types
of phenomenon and techniques that depend upon a different type of polymers and excipients used
in the formulation.