In Situ Gelling Nasal Drug Delivery System


V.T. Mankoskar, Corresponding Author,  G. V.Lohiya, R.R.Sarda,
Dayanand College of Pharmacy, Latur, Maharashtra, India.
R. M. Somani
Macleods Pharmaceuticals Ltd, Mumbai, Maharashtra, India.
Dr. S.S.Dharashivkar
Dr. L. H. Hiranandani college of Pharmacy, Ulhasnagar, Maharashtra, India.
Dr. S. G. Gattani
School of Pharmacy, S.R.T.M. University, Nanded, Maharashtra, India.
Dr. S.S.Tiwari
Annasaheb Dange College of B.Pharmacy, Ashta, Sangli, Maharashtra, India.


In the nasal cavity, nasal mucosa had a high blood perfusion rate, due to this the absorption of the drug is high as compared to other routes, as well as has increased good bioavailability of drugs at the systemic circulation. To improve the nasal retention time of in-situ gel with nasal mucosa we have to use bio-compatible mucoadhesive polymer. In-situ gel nasal drug transfermethod is the type of mucoadhesive drug delivery system. When the drug is administered through nasal route then the first-pass metabolism gets reduced, had less enzymatic reaction occurrence, and prevents gastrointestinal tract ulceration. Drug release kinetic can be controlled by gelation strength of the formulation and viscosity of the in-situ gel formulation, so in-situ gel nasal drug delivery is also called a controlled and sustained drug delivery system. In-situ gels are prepared by various types of phenomenon and techniques that depend upon a different type of polymers and excipients used in the formulation.