In vivo Antidiabetic Potential of Momordica charantia and Trigonella foenum graecum Seed Extracts in Nicotinamide- Streptozotocin Administered Diabetes Induced Rats

Diabetes mellitus is a metabolic disorder initially characterized by a loss of glucose homeostasis with disturbance of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action or both. Antidiabetic potential of Momordica charantia seed (MCS) and Trigonella foenum graecum seed (TGS) extracts were evaluated in Streptozotocin – Nicotinamide (STZ-NIC) administered diabetes induced rats. In OGTT (Oral Glucose tolerance Test), MCS, TGS and glibenclamide treated rats significantly prevented a rise of the blood glucose level compared to the control group. Diabetes Mellitus was induced by a single intraperitoneal injection of STZ-NIC and rats with blood glucose concentration more than 250mg/dl were used for further study. The rats were divided into seven groups and treated with MCS, TGS and glibenclamide for of 21 days. Rats treated with MCS 400 mg/kg b.w and TGS 400 mg/kg b.w. showed significant decrease in the levels of blood glucose monitored at weekly intervals. Rats treated with plant extracts and glibenclamide showed a significant increase (p<0.05) in the total protein content and in liver glycogen.