Influence of Artocarpus heterophyllus in benzopyrene induced lung cancer

Lung cancer a deadliest cancer worldwide and the most common cancer in the whole of Asia. The present study focused on the protective efficacy of Artocarpus heterophyllus in benzopyrene induced lung toxicity in C57BL/6 Mice. Mice were orally induced with benzopyrene and treated with hydroethanolic extract of spermoderm of Artocarpus heterophyllus (HESA) at a dose of (50mg/kg.b.wt and 100mg/kg.b.wt). The oral administration of HESA effectively suppressed lung cancer as revealed by the decrease in the extent of haematological parameters with concomitant decrease in the activities of serum markers. Significantly protein expressions of p53 and Bcl2 in the lung tissue were further confirmed that coadministration of the extract treatment however downregulated their expressions by decreasing the marker of positively stained cells and restored the histopathological alteration of lung tissue. Our results suggest that HESA can be used as a protective agent against benzopyrene induced lung cancer.