Rutumbhara patil, shivani patil, snehal patil, Vaishanavi pakhare, Dr. vijay. R. salunkhe
Rajarambapu college of pharmacy, kasegaon, Walwa, Sangli District, Maharashtra, India.
Liposome: An overview
Authors
Abstract
The self-forming encapsulated lipid bilayer that results from hydration resulted to
the term "liposome" or "lipid vesicle."Nanosized drug delivery techniques known as
liposomes are significant. Concentric phospholipid bilayer molecules with a range in
molecular weight from low to high have been combined into liposomes. Water-soluble
substances and drugs are found in aqueous compartments, whereas lipid-soluble substances
and amphiphilic substances insert themselves in phospholipid bilayers. The spherical sac
vesicle has at least one lipid bilayer and is composed of lipids. Drug delivery size and size
distribution are the primary purposes for liposome development. The key important factor in
developing potent drugs is enhancing the therapeutic result. The primary goal of liposome
formulation is to increase accumulation at the target site; the subsequent effect is then
intended to diminish toxicity. Numerous techniques, including hydration, ethanol injection,
ether injection, sonication, and micro-emulsion, French extrusion technique for pressure
cells are used to create liposomes.The main drawback of this dosage form is very expensive
and time-consuming the process. However, it has important uses such as homogenous size
extrusion, long circulating liposomes, triggered release liposomes, remote drug loading,
ligand targeted liposomes, and containing combination of drug.