Liposome: An overview


Rutumbhara patil, shivani patil, snehal patil, Vaishanavi pakhare, Dr. vijay. R. salunkhe
Rajarambapu college of pharmacy, kasegaon, Walwa, Sangli District, Maharashtra, India.


The self-forming encapsulated lipid bilayer that results from hydration resulted to the term "liposome" or "lipid vesicle."Nanosized drug delivery techniques known as liposomes are significant. Concentric phospholipid bilayer molecules with a range in molecular weight from low to high have been combined into liposomes. Water-soluble substances and drugs are found in aqueous compartments, whereas lipid-soluble substances and amphiphilic substances insert themselves in phospholipid bilayers. The spherical sac vesicle has at least one lipid bilayer and is composed of lipids. Drug delivery size and size distribution are the primary purposes for liposome development. The key important factor in developing potent drugs is enhancing the therapeutic result. The primary goal of liposome formulation is to increase accumulation at the target site; the subsequent effect is then intended to diminish toxicity. Numerous techniques, including hydration, ethanol injection, ether injection, sonication, and micro-emulsion, French extrusion technique for pressure cells are used to create liposomes.The main drawback of this dosage form is very expensive and time-consuming the process. However, it has important uses such as homogenous size extrusion, long circulating liposomes, triggered release liposomes, remote drug loading, ligand targeted liposomes, and containing combination of drug.