Microwave Assisted Synthesis, Molecular Docking Studies and Anticancer Screening of Some 1,3,4-thiadiazole Derivatives

1,3,4-thiadiazole derivatives were prepared by different substituted nitrobenzene and evaluated for anticancer activity. Resistance to these anticancer agents has posed a great hindrance in successful treatment of cancer. Pondering this ongoing situation, it was speculated to develop novel compounds targeting cancer. All the newly synthesized compounds code 3a-d were further evaluated for anticancer activity against MCF-7 cell lines using MTT assay. Molecular docking studies were performed using VLife MDS 4.3 software. Compound code 3b exhibited good docking scores of -69.14. The findings indicated that every by MTT showed substantial behavior, including MCF-7. Compound code 3b finds itself more promising anticancer agents by comparing with standard drug as 5-fluorouracil. The anticancer and docking results highlight the fact that the synthesized compound code 3b could be considered as possible hit as therapeutic agents. A significant correlation was observed between the in-silico and the in-vitro studies.