Thiazole is a good pharmacophore nucleus due to its various pharmaceutical applications. Its
derivatives have a wide range of biological activities such as antioxidant, analgesic, and
antimicrobial including antibacterial, antifungal, antimalarial, anticancer, antiallergic,
antihypertensive, anti-inflammatory, and antipsychotic. A series of novel 2-aminothiazole
derivatives were synthesized by microwave assisted method as a green chemistry approach
and were characterized by spectral methods and elemental analysis. The antioxidant
potential of the derivatives was determined by using molecular docking against two different
oxidoreductase protein (PDB: 2CDU and 3NM8). Compound 3a and 3d shows the stronger
binding affinity to the targeted protein. The synthesised drug was pharmacologically
evaluated for the antioxidant activity using ascorbic acid as a reference drug. Compound 3a
shows highest inhibition.
