Microwave Assisted Synthesis of 2-Aminothiazole Derivatives

Thiazole is a good pharmacophore nucleus due to its various pharmaceutical applications. Its derivatives have a wide range of biological activities such as antioxidant, analgesic, and antimicrobial including antibacterial, antifungal, antimalarial, anticancer, antiallergic, antihypertensive, anti-inflammatory, and antipsychotic. A series of novel 2-aminothiazole derivatives were synthesized by microwave assisted method as a green chemistry approach and were characterized by spectral methods and elemental analysis. The antioxidant potential of the derivatives was determined by using molecular docking against two different oxidoreductase protein (PDB: 2CDU and 3NM8). Compound 3a and 3d shows the stronger binding affinity to the targeted protein. The synthesised drug was pharmacologically evaluated for the antioxidant activity using ascorbic acid as a reference drug. Compound 3a shows highest inhibition.