Nanocrystalisation by Anti-Solvent Precipitation Technique for Solubility and Dissolution Enhancement of Telmisartan

Solubility is the parameter to achieve desired concentration of drug in systemic circulation for therapeutic response to be shown. There is a need for systematic formulation approaches to make such poorly soluble drugs bioavailable. Telmisartan is an angiotensin II receptor antagonist used in the management of hypertension. Nanocrystals were prepared by antisolvent precipitation method using dimethyl formamide as solvent, water as antisolvent and PVPK30 as stabilizer. The preparations were characterized in terms of particle size, nature, Stability, dissolution. Prepared nanocrystal samples showed increased solubility than the pure sample in water and increased nearly more than two-fold higher (107.64 μg/ml) than pure Telmisartan (50 μg/ml). Telmisartan was stable in the formulation and absence of any interaction between the drug and the polymer. Increase in crystalline nature in formulation as compared to pure Telmisartan. The dissolution of Telmisartan tablets containing nanocrystal formulation exhibited improved dissolution behavior than tablets prepared by pure Telmisartan i.e., Marketed formulation of Telmisartan.