Novel Cu(II)-Drug derivative from Cefotaxime: Synthesis, Spectroscopy, Thermal analysis, Biological Activity


Mustafa S. Abd El-Zahir (Corresponding Author), Hamdy A. ELKady
Department of Science and Mathematics Engineering, Faculty of Petroleum and Mining Engineering, Suez University, Suez, 43512, Egypt.

Mohamed H. A. Soliman
Chemistry department, Faculty of Science, Suez University, Suez, Egypt.

Adel S. Orabi
Chemistry department, Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt.


Copper complex is synthesized from Schiff base ligand which is a new cefotaxime derivative. The composite is characterized by molar conductance, elemental analysis (CHNM%), FTIR, magnetic moment, UV–Vis spectrum and thermal analysis. The complex stoichiometric ratio is found to be 1 metal : 1 ligand ratio. The FTIR frequencies display that the Schiff base works as bidentate and coordinated to copper ion through oxygen atoms of carboxylate and carbonyl beta lactam group. While, the electronic transition, magnetic moment value and ESR spectrum indicate that the Cu-composite geometry is an octahedral. Furthermore, thermal analysis confirms the existence of methanol and water molecules in the compound. Meanwhile, the Cu-composite is scanned against Gram (+) bacteria (B. subtilis and S. aureus) and Gram (-) bacteria (E. coli and P. aeruginosa). The obtained data shows that the compound has good antimicrobial activity.