Novel Transition Metal Chelators Acts as an Antibiotics: Synthesis, Characterization and Anti-Biogram Assay

In the present research work, a series of novel thiazole derivatives of Schiff base metal complexes [Cu(II), Co(II), Ni(II) and Zn(II)] has been synthesized and characterized by various physicochemical and spectroscopic techniques. The synthesized complexes showed significant antibacterial activity against the organisms Bacillus subtilis and Escherichia coli when compared with the standard antibiotic Streptomycin. The antimicrobial screening emphasize the higher activity exhibited by these complexes which have a highly conjugative planar ligand, 2-amino- 6-methylbenzothiazole in its natural environment. The results indicated that Cu(II) complex could be responsible for the potential contender eliciting antimicrobial activity. It can be attributed to the combined effect of the substituents and thiazole structural core present in the ligands. The results showed Cu(II) and Co(II) compounds had absolute specificity for these organisms, which implied a good application prospect in pharmaceutical probes.