Pharmacognostic and Phytochemical Investigation, Molecular Docking Studies of Phytoconstituents and Anticancer Potential of Capparis Decidua (Forsk) Edgew


Rushikesh M. Birajdar, Akshay R. Yadav, Smita R. Patil, Ankita V. Chitruk, Dr. Sandeep R. Kane, Dr. Shrinivas K. Mohite, Dr. Chandrakant S. Magdum
Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Sangli, Maharashtra, India.


Capparis decidua (Forsk.) Edgew. belonging to family Capparidaceae is well known for curing a variety of ailments such as toothache, cough, asthma, intermittent fever and rheumatism. The present study was undertaken to investigate the pharmacognostical and phytochemical parameters Capparis decidua. The Molecular docking analysis of the target proteins with the phytochemical ligands was performed using VLifeMDS software. The docking scores and analysis of the interactions of the phytoconstituents with target proteins suggests that phytoconstituents like palmitic acid have the ability to bind to multiple targets. Brine shrimp model that may prove quite helpful as a preliminary screening to determine toxic properties. In Brine shrimp lethality bioassay, extracts produced dose dependent cytotoxicity effect to brine shrimp nauplii. Antiproliferative and cytotoxic effects of the Capparis decidua methanolic extract was determined using MTT assay and shows significant anticancer activity.