Pharmacological Importance And Chemistry Of 1,3,4-Oxadiazole Derivatives

Authors

Abhishek V. Desai, Mayuri V. Bhosale, Mayuri S. Bhadalekar, Vinayk Y. Rohile, Pritam A. Salokhe,
Assistant professors, Ashokrao Mane Institute of pharmacy, Ambap, Maharashtra, India.

Dr. N.B.Chougule, principal
Ashokrao Mane Institute of pharmacy, Ambap, Maharashtra, india.

 

Abstract

Oxadiazole is an important heterocyclic compound containing one oxygen and two nitrogen atoms in the five membered ring. 1,3,4-oxadiazole is a versatile heterocyclic nucleus having novel molecule which attract the medicinal chemist to search a new therapeutic molecule. The present review summarizes physicochemical properties, various synthetic procedures and various pharmacological activities of 1,3,4-oxadiazole moiety. 1,3,4-oxadiazole moiety is an important pharmacophore which plays a major role in the pharmaceutical chemistry and broad range of important biological activities such as anti-inflammatory, analgesic, ulcerogenic, antimicrobial, antifungal antitubercular, anticonvulsant, anticancer/antitumor, antiviral, and antihypertensive activities etc. as reported in the literature.