Renal function outcome and antidyslipidaemic effect of polyherbal crude extract in Isoproterenol-Induced Oxidative Damage in Rat Myocardium

Cardiovascular disease has become a universal cause of morbidity and largely contributes to mortality in developed and developing countries. The present study aimed to evaluate the antidyslipidemic effect and renal outcome of polyherbal extract on isoproterenol induced myocardial infarction in Wistar albino rat model. The rats were divided into eight groups of six animals each. Group, I served as normal control, Group II rats were administered isoproterenol (20mg/g B.wt). Group III and IV were pretreated with PH extract (250 mg/kg B.wt, 500mg/kg B.wt, respectively) for 30 days and received a subcutaneous injection of isoproterenol (20mg/kg, B.wt) at the end of the experimental period for 2 consecutive days. Group V and VI were pretreated with Propranolol (10 mg/kg B.wt, 20mg/kg B.wt) for 30 days and received a subcutaneous injection of isoproterenol (20mg/kg, B.wt) at the end of the experimental period for 2 consecutive days. Group VII and VIII received PH extract of 250mg/kg B.wt and 500mg/kg B.wt for 30 days. After the experimental period, blood was collected, serum was separated and used for the estimation of renal and Lipid profiles are studied to access the cardioprotection. The levels of the renal profile(serum urea, uric acid and creatinine), and lipid profiles, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and phospholipids (PL), triglycerides (TG) and Free Fatty acids (FFA) was significantly increased, while the levels of high-density lipoprotein cholesterol (HDL-C) in serum of IPL treated rats. In PH pretreated rats the renal and dyslipidaemic effects of IPL were compensated to near normal levels. The study shows that the extract has a significant antidyslipidaemic effect.