Role of FOXO3 Gene Polymorphism at Development of Primary Knee Osteoarthritis Disease in Iraqi Patients


Inas Adnan Yahya
Higher Health Institute Alkhadmia / Iraq.


Primary Knee osteoarthritis (PKOA) is disease occur in knee joint characterize by cartilage degradation that mediate via pro-inflammatory marker such as matrix metalloproteinase-13 (MMP-13) . Forkhead box (FoxO ) proteins are a subgroup of the Forkhead family of transcription factors ,which were originally identified in Drosophila as a gene whose mutation resulted in ectopic head structures that look like a fork . Cartilage cells obtained from human joints affected by OA , the cells had a reduced activity of genes producing FoxO proteins and reduced activity of autophagy genes.