Synthesis, Molecular Docking Studies and Anticancer Activity of 1,3,4-Oxadiazole-3(2H)-thione Derivatives

1,3,4-oxadiazole derivatives are recognized to possess various biological activities as antiparasitic, antifungal, antimicrobial and antiproliferative. The present work reports the synthesis of four new derivatives under microwave irradiation with the purpose of developing new drugs that present high specificity for tumor cells and low toxicity to the organism. All the newly synthesized compounds 3a-d were further evaluated for anticancer activity against MCF-7 cell lines using MTT assay and compound code 3c could be considered as possible hit as therapeutic agents. The study draws a very good relationship in-silico and in-vitro anticancer activity and the antitumor potential of the cytotoxic compounds.