The Leptin Level in Development of Knee Osteoarthritis Disease

Subject: Knee Osteoarthritis (HOA) is known as degenerative cartilage cell disease in joint association with generation various inflammatory responses. This disease is more common in geriatrics and affected by many factors such as obesity. Leptin is hormones secreted by fatty tissue involve as a mediator in many pathophysiology processes, and supports inflammation at the cartilage of the knee joint. The objective of the Study: Role of the leptin concentration level in the progression of knee Osteoarthritis. Materials and Methods: This study was done on 60 patients with KOA disease and 60 healthy persons (control ), the all subject’s age within this study was more than 60 years of both genders. After obtained serum, immediately used quantity method (immunoassay) for the measured level of leptin concentration. Results: This study shows elevation of serum leptin concentration level in the KOA group compared with the healthy control group. Conclusion: This study confirms that serum leptin concentration level can act as support KOA disease progression.