Toxicological Assessment using Brine Shrimp Lethality Assay and Antimicrobial Activity of Capparis Grandis


Vaibhav S. Suryawanshi, Akshay R. Yadav, Dr. Shrinivas K. Mohite, Dr. Chandrakant S. Magdum
Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Dist. Sangli, Maharashtra, India.


Medicinal plants constitutes an important component of flora and are widely distributed in India. The pharmacological evaluation of substances from plants is an established method for the identification of lead compounds which can leads to the development of novel and safe medicinal agents. Based on the ethnopharmacological literature, several species of medicinal plants used in traditional medicine in india were collected. In the present study, Capparis grandis extracts were screened for cytotoxicity using brine shrimp lethality test. The present studies widen the scope of the brine shrimp model that may prove quite helpful as a preliminary screen to determine toxic properties. In Brine shrimp lethality bioassay, compounds produced dose dependent cytotoxicity effect to brine shrimp nauplii and Capparis grandis extract were screened for antimicrobial activity, ethanolic and methanolic extracts shows significant activity.