Preparation and Evaluation of Etodolac Loaded Copper Nanoparticles

Rheumatoid arthritis is most prevalent chronic inflammatory joint disease. Inflammation is biological response of homeostasis of the damaged tissue. At this fundamental stage, it is a tissue-destroying method involving the recruitment into the disturbed tissue of blood-derived product such as a plasma protein, fluid and leucocytes. Inflammation is prevalent pathogenesis of numerous chronic diseases, involving cardiovascular and intestinal illness, diabetes, arthritis and cancer. Pain is generally occurring arthritis pain is elicited by activation of afferent sensory nerve fibers (C-fibers) in inflamed despite regression of inflammatory signs. Rheumatoid arthritis is chronic damaged in synovial membrane that’s lead to synovitis and damaged of joint architecture resulting in pulmonary, ocular, vascular and other organs structure affect by inflammatory process. The aim of this research is to increase the solubility and effectiveness of water insoluble Etodolac. The goal of this work is to develop etodolac conjugate copper nanoparticles and enhance its solubility by lessen the size to nanometer scale. Preformulation studies were carried out. Total nine batches were prepared by using copper sulphate as precursor and hydrazine hydrate as reducing agent. FTIR spectroscopy indicates that there is no formation of any other compound. Copper nanoparticles were synthesized with chemical reduction method. After preparation of copper nanoparticles were subjected to various evolution parameters including % drug release, SEM, Particle size analysis, FTIR and Solubility.